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Novedades Abril 2026

PLoS One. 2026 Feb 23;21(2):e0342704. doi: 10.1371/journal.pone.0342704. eCollection 2026.

Autores:

Mengru Wang  1 , Fudong Hu  2 , Rongyan Jiang  1 , Sheng Tu  1

Conclusión: The Lp(a)-CatLet© synergy enhances MACCE risk stratification in ePCI-treated AMI, reflecting complementary pathobiological (Lp(a)-driven plaque vulnerability) and anatomical (CatLet©-quantified complexity) pathways. This dual-parameter approach could support post-PCI risk stratification and follow-up planning.

Cardiol J. 2026:33:e00226010. doi: 10.5603/cj.108082. Epub 2025 Oct 16.

Autores:

Tomasz Saniewski  1   2 , Grzegorz Procyk  3   4 , Jakub Zimodro  3   4 , Olivia Wasilewska  5 , Bartosz Mroczyk  5 , Michał Lis  5   6 , Aleksandra Gąsecka  3

Conclusión: High Lp(a) is prevalent in the Polish population, and thus it is important to measure it routinely in each individual at least once in a lifetime and control all other known cardiovascular risk factors to decrease the overall risk.

Curr Opin Lipidol. 2026 Apr 1;37(2):65-72. doi: 10.1097/MOL.0000000000001030. Epub 2026 Feb 6.

Autores:

Stefan Coassin  1

Conclusión: Technological advances establish a foundation for more accurate genetic risk assessment across ancestries. These advances are enhancing our understanding of Lp(a) regulation and build a framework for future integrative genetic studies, which may shed new light on the evolution of the Lp(a) trait, adding important context for its physiological and clinical relevance.

Curr Opin Lipidol. 2026 Apr 1;37(2):58-64. doi: 10.1097/MOL.0000000000001024. Epub 2026 Jan 28.

Autores:

Arya Aminorroaya  1   2 , Rohan Khera  1   2   3   4   5

Conclusión: Machine learning-based strategies provide a scalable means of operationalizing universal Lp(a) testing recommendations within health systems. When developed using unbiased data, externally validated, and assessed for fairness and interpretability, these models can support systematic identification of individuals with elevated Lp(a) and integration of Lp(a) measurement into routine cardiovascular risk assessment.

J Clin Lipidol. 2026 Feb;20(2):317-325. doi: 10.1016/j.jacl.2025.12.002. Epub 2025 Dec 4.

Autores:

Shoshana H Bardach  1 , Skye Chernichky-Karcher  2 , Allison Hawke  3 , Diane MacDougall  3 , Katherine Wilemon  3 , Laurence S Sperling  4

Conclusión: This analysis highlights that Lp(a) testing decisions are multifactorial, providing multiple opportunities for intervention and improvement. Strategies to convey how Lp(a) measurement can inform risk assessment and treatment approaches may be foundational to encouraging more widespread testing.

Conclusión: There is some evidence that Lp (a) levels are an independent risk factor for MACE in patients who underwent PCI for CAD. There is also some evidence that elevated Lp (a) levels are associated with a worse prognosis in patients with DM after PCI, but this association is not consistent in the literature. Further prospective multicenter studies are required in order to elucidate this association.

Clin Investig Arterioscler. 2026 Mar-Apr;38(2):500870. doi: 10.1016/j.arteri.2025.500870. Epub 2025 Oct 18.

Autores:

Rosa Fernández-Olmo  1 , Jesús Lara Mariscal  2 , Ana García Ruano  3 , Alberto Cordero  4 , Juan Manuel Castillo Casas  5 , Diego Franco  5

Conclusión: Studies evaluating the impact of Lp(a) on outcomes in CABG patients are few, with heterogenous cut-offs and outcomes. In the limited published studies, Lp(a) level was not associated with graft occlusion.

J Assoc Physicians India. 2026 Feb;74(2):33-37. doi: 10.59556/japi.74.1331.

Autores:

Sonali Sharma  1 , Ramesh Kumar Chandak  2 , Krishna Kumar Sharma  3 , Soneil Guptha  4 , Rajeev Gupta  5

Conclusión: Substantial variation in coronary artery disease (CAD) risk prediction using various clinical algorithms is observed in T2D. The EAS algorithm provides the most robust estimate. The addition of Lp(a) to the risk algorithms augments risk stratification significantly. The results of this pilot study need confirmation with larger prospective studies.

Pharmacol Ther. 2026 May:281:109010. doi: 10.1016/j.pharmthera.2026.109010. Epub 2026 Feb 20.

Autores:

Elias Björnson  1 , Chris J Packard  2 , Jan Borén  3

Am J Med Sci. 2026 Apr;371(4):336-344. doi: 10.1016/j.amjms.2025.12.002. Epub 2025 Dec 5.

Autores:

Yan-Yan Li  1 , Hui Wang  2 , Yang-Yang Zhang  3

Conclusión: LPA rs3798220 and rs10455872 polymorphisms were significantly associated with increased CAD risk. The persons carrying C allele of LPA rs3798220 and G allele of LPA rs10455872 polymorphisms might have higher CHD risk than the T allele of rs3798220 or A allele of rs10455872 carriers.

Conclusión: Elevated Lp(a) levels were independently associated with maladaptive left ventricular and left atrial remodeling in Hispanic adults over a decade, while no statistically significant relationships were observed in White, Black, and Chinese participants. This suggests a unique susceptibility of Hispanic individuals to Lp(a)-mediated cardiovascular remodeling, independent of ischemic pathways.

J Clin Lipidol. 2026 Mar;20(3):671-676. doi: 10.1016/j.jacl.2026.01.018. Epub 2026 Jan 27.

Autores:

Jadry Gruen  1 , Archna Bajaj  2

Conclusión: Ahead of results from ongoing clinical trials testing Lp(a)-targeted therapies, health systems can use QI methods to assess current Lp(a) ordering practices, identify patients who may benefit from future Lp(a)-targeted therapy, and plan for rapid expansion of Lp(a) testing.

Conclusión: Higher Lp(a) values are associated with LAA stroke, particularly ICAS. Lp(a) levels should be included in the stroke workup.

Curr Med Res Opin. 2026 Jan;42(1):19-24. doi: 10.1080/03007995.2026.2627735. Epub 2026 Feb 11.

Autores:

Andreas Tridimas  1   2 , Suha Ahmed  3

Conclusión: Routine Lp(a) testing meaningfully alters management and reveals a form of residual dyslipidaemia resistant to standard therapy. These findings, combined with recent cost-effectiveness modelling showing NHS and societal savings from one-time testing, support incorporation of Lp(a) measurement into universal cardiovascular risk assessment.

Conclusión: Elevated Lp(a) levels were observed in 8.3% of the general population cohort and up to 23.9% in participants with ASCVD from the lipid clinic cohort, highlighting a risk gradient across ASCVD categories. Incorporating Lp(a) as a risk enhancer improves ASCVD risk reclassification beyond the validated HellenicSCOREII+.

Diabetes Obes Metab. 2026 Apr;28(4):3044-3053. doi: 10.1111/dom.70491. Epub 2026 Jan 21.

Autores:

Zenglei Zhang  1 , Lin Zhao  2 , Zeyu Wang  1 , Xianliang Zhou  1 , Xianlun Li  2 , Weixian Yang  1 , Xu Meng  1

Conclusión: Elevated Lp(a) levels were associated with a higher risk of ASCVD across different glucose metabolism statuses, particularly among individuals with NGR and prediabetes, independent of baseline CRP levels.

Endocr Regul. 2026 Mar 24;60(1):1-11. doi: 10.2478/enr-2026-0001. Print 2026 Jan 1.

Autores:

Heri-Nugroho  1 , Nurdopo Baskoro  2 , Charles Limantoro  3 , Andreas Arie Setiawan  3 , Anugrah Riansari  1 , Risa Ardiani  4

J Lipid Res. 2026 Mar;67(3):101008. doi: 10.1016/j.jlr.2026.101008. Epub 2026 Feb 23.

Autores:

Santica M Marcovina  1 , Spenser Smith  2 , Lizhu Lin  3 , Sotirios Tsimikas  4

J Lipid Res. 2026 Mar;67(3):100996. doi: 10.1016/j.jlr.2026.100996. Epub 2026 Feb 10.

Autores:

Lizhu Lin  1 , Fei Su  1 , Calvin Yeang  1 , Sotirios Tsimikas  2

J Cardiovasc Pharmacol. 2026 Apr 1;87(4):229-241. doi: 10.1097/FJC.0000000000001794.

Autores:

Xinyan Li  1   2 , Zhongsu Wang  1 , Juan Liang  1 , Bingsong Li  1 , Qingxin Meng  1   2 , Mei Gao  1

Conclusión: Point of care testing could be a complimentary option to laboratory testing of lipoprotein(a), especially in remote areas. It may help (re-)stratify cardiovascular risk and help tailor treatment decisions.

Conclusión: Health professionals working in CVD care should be aware of the need to investigate patients with coronary disease for Lp(a) and be equipped to give advice on how to reduce overall cardiovascular risk especially given the absence of licenced therapies to treat Lp(a).

Conclusión y Relevancia: In this cohort study of 10 519 adults, adding apoB to PREVENT-estimated ASCVD risks was associated with improved risk reclassification, particularly in younger adults. However, the clinical importance of these modest improvements remains uncertain.

Clin Cardiol. 2026 Apr;49(4):e70289. doi: 10.1002/clc.70289.

Autores:

Yongmei He  1 , Jun Liu  1 , Jingwei Zhuang  1 , Hongjia Hu  1

Conclusión: Elevated Lp(a) is associated with an increased HF risk in a nonlinear pattern, with risk escalation slowing at higher concentrations.

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(3. Vyp. 2):5-11. doi: 10.17116/jnevro20261260325.

[Article in Russian]

Autores:

N V Pizova  1 , A V Pizov  2

Conclusión: Lp(a) testing was associated with increased LLTI and LDL-C goal attainment. Elevated Lp(a) identified individuals more likely to undergo LLTI, suggesting testing may motivate preventive treatment optimization.

Conclusión: In patients with CAD, elevated Lp(a) and DM act synergistically to increase the risk of cardiovascular and all-cause mortality, suggesting that both risks should be considered to integrate management.

Conclusión: Ox-HDL-C, ox-LDL-C and ox-Lp(a) are independent, dose-dependent predictors of T2DM development in individuals with prediabetes. Their close association with impaired β-cell function highlights their potential utility in early risk stratification and targeted prevention strategies for T2DM.

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(3. Vyp. 2):5-11. doi: 10.17116/jnevro20261260325.

[Article in Russian]

Autores:

N V Pizova  1 , A V Pizov  2

Clin Cardiol. 2026 Apr;49(4):e70289. doi: 10.1002/clc.70289.

Autores:

Yongmei He  1 , Jun Liu  1 , Jingwei Zhuang  1 , Hongjia Hu  1

Conclusión: Elevated Lp(a) is associated with an increased HF risk in a nonlinear pattern, with risk escalation slowing at higher concentrations.

Conclusión y relevancia: In this cohort study of 10 519 adults, adding apoB to PREVENT-estimated ASCVD risks was associated with improved risk reclassification, particularly in younger adults. However, the clinical importance of these modest improvements remains uncertain.

Conclusión: High Lp(a) level in patients who underwent PCI with DES was associated with poor prognosis; however, the predictive value of Lp(a) in this population remains inconclusive.

Conclusión: High Lp(a) level in patients who underwent PCI with DES was associated with poor prognosis; however, the predictive value of Lp(a) in this population remains inconclusive.

J Am Heart Assoc. 2026 Apr 21;15(8):e045533. doi: 10.1161/JAHA.125.045533. Epub 2026 Apr 9.

Autores:

Rebecca K Kelly  1   2 , Katie Harris  1 , Paul Muntner  3   4 , Mark Woodward  1   5

Conclusión: Men had a higher rate of CVD than women overall. Low-density lipoprotein cholesterol, apoB and Lp(a) had stronger associations with CVD risk in men, whereas triglycerides were stronger in women. ApoA1 was less protective for CVD in women than men.

Atherosclerosis. 2026 Apr:415:120723. doi: 10.1016/j.atherosclerosis.2026.120723. Epub 2026 Mar 24.

Autores:

Iyas Daghlas  1 , Marios K Georgakis  2 , Stephen O Brennan  3 , Benoit J Arsenault  4 , Stephen Burgess  5 , Dipender Gill  6

Conclusión: These findings suggest that Lp(a) minimally mediates and does not modify the cardiovascular benefits of IL-6 signaling inhibition, supporting these targets as independent and complementary for ASCVD. The amplified IL-6-Lp(a) association in carriers of Lp(a)-raising variants warrants replication.

Atherosclerosis. 2026 Apr:415:120706. doi: 10.1016/j.atherosclerosis.2026.120706. Epub 2026 Mar 13.

Autores:

Sneha Annie Sebastian  1 , Tia Bimal  2 , Tanesh Ayyalu  3 , Natasha Vartak  4 , Harpreet S Bhatia  5 , Sotirios Tsimikas  5

Conclusión: High-risk Lp(a) is associated with greater coronary plaque prevalence, accelerated progression, and increased LAP. These findings underscore Lp(a) as a driver of high-risk, rupture-prone plaques and a critical biomarker and potential therapeutic target in cardiovascular risk management.

Conclusión: Elevated Lp(a) concentrations were causally associated with ASCVD risk, showing a predominantly graded relationship with possible nonlinearity at very high levels, supporting routine Lp(a) measurement and the development of Lp(a)-lowering therapies.

J Clin Lipidol. 2026 Apr;20(4):789-796. doi: 10.1016/j.jacl.2026.02.001. Epub 2026 Feb 10.

Autores:

Prachi Bajpai  1 , Mukta Mantan  2 , Akanksha Mahajan  3 , Aashima Dabas  4 , Bhawna Mahajan  5

Conclusión: Identification of dyslipidemia using conventional parameters may lead to overdiagnosis in nephrotic syndrome during disease remission; the ApoB/ApoA-1 ratio appears to be a better marker.

J Clin Lipidol. 2026 Apr;20(4):828-832. doi: 10.1016/j.jacl.2026.01.016. Epub 2026 Jan 27.

Autores:

Lakshmi Lakkineni  1 , Matthew Waite  2 , Alessia David  3 , Ben Jones  4 , Jaimini Cegla  5

Conclusión: Hence, repeat Lp(a) testing is generally unnecessary but could be considered in those near risk thresholds or those being evaluated for Lp(a)-lowering therapies.

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